RFdiffusion2

5-30 minutesPaperCodeNeed >20GB

Enzyme active site scaffolding with atom-level or residue-level motif specification

Readiness

Readiness: Need >20GB
Smoke: passed
Artifacts: passed
Production: need_gt20gb_rfdiffusion2_official_sif_bundle_pending
Storage: >20GB
Strategy: Budget/install official RFdiffusion2 SIF bundle and weights under shared containers/cache; avoid duplicating Chai/RFD assets where possible.
Next: Free or allocate at least 35-40GB headroom, download official RFdiffusion2 SIFs and weights, run motif/ligand sample through Slurm, then wire real adapter.

generative structure/design model weights likely >5GB 2026-07-17T01:18:00+08:00 SOP Need >5GB next-10 audit: remains Need >5GB. Local registry maps to rfdiffusion2-smoke and cluster_tools routes it to generic genie_backbone_smoke; backend shared storage had no RFdiffusion2 runtime/checkpoint assets. Needs real RFdiffusion2 SIF/overlay and motif-scaffolding smoke. 2026-07-18T21:37:01+08:00 SOP Need >5GB batch source-staging: Official RFdiffusion2 repo cloned to backend /media/nik/seagate_nik/bio_server/repos/rfdiffusion2 at d365cbf (881MB). Agent audit found official setup assets exceed 20GB: bakerlab_rf_diffusion_aa.sif about 13.58GB, mlfold.sif about 6.25GB, chai.sif about 8.40GB, plus RFD/LigandMPNN weights, totaling about 30.9GB before overhead. With 37GB free this is possible but tight and should be budgeted as a very-large install.