ESMFold2 Binder Design

30-60 minutesPaperCodeNeeds Token/License

Design de novo protein binders against a target

Readiness

Readiness: Needs Token/License
Smoke: passed
Artifacts: passed
Production: needs_token_modal_or_local_protocol_port_esmfold2_binder_design
Storage: token/protocol gated
Strategy: Modal-backed official protocol or local Slurm port after ESMFold2/ESMC runtime staging.
Next: Either provide Modal credentials for the official binder_design.py deployment path, or approve/implement a local Slurm port after base ESMFold2 and ESMC critic weights are staged; then validate one target/binder job and wire a real adapter.

2026-07-18T17:33:47+08:00 SOP large-tool batch: remains Need >5GB. It depends on the Biohub ESMFold2 stack plus binder-design protocol/wrapper; no real binder-design runner or benchmark is staged. Current runner is esmfold2-binder-design-smoke placeholder. 2026-07-18T18:39:16+08:00 SOP Need >5GB active batch: Official Biohub binder-design tutorial/script uses Modal deployment and token flow plus ESMC-6B/ESMFold2 critic stack. Base ESMFold2 remains public-local, but the exact official binder-design path needs Modal credentials or a deliberate local port before production validation.